Analgesic effects of aqueous extract of Teucriun polium L. in experimental models of pain in male rats

There are some reports in ancient medicinal literature that aqueous extracts of the leaves of Teucrium polium show analgesic effects. This prompted us to investigate the analgesic effect of the leaves of the plant using Tail-Flick and Fomalin tests. For this purpose, male NMRI rats weighing 220-260 g were used in all experiments. The aqueous extract of the plant was injected intraperitoneally at doses of 150, 200 and 400 mg/kg. In this study, sodium salicylate (100 and 300 mg/kg) and distilled water were used as positive and negative controls, respectively. The results obtained were analyzed using one-way ANOVA and Tukey-Kramer tests. Our data showed that intraperitoneal injection of aqueous extract of leaves of this plant (150, 200 and 400 mg/kg) produces significant analgesia in both phases of the formalin test (P